Nikki Glaser never holds back right? The comedian is always dropping truth bombs and her recent appearance on "The Tonight Show Starring Jimmy Fallon" was no different. She got into some hot topics like Ozempic plastic surgery and even a kinda gross but funny airport story. Get ready because Nikki's takes are as funny as they are blunt.
Nikki Glaser's Ozempic Stance: 'Hell Yeah Girl Do It!' and Why She Thinks Critics Are Just Jealous
Ozempic is everywhere these days especially in Hollywood. Jimmy Fallon asked Nikki what she thought about the weight-loss drug and her response? Total support. She is all in on Ozempic. Nikki said "Oh I love it I love it. I’m like do it do it. I have no judgment." She wants people to feel okay talking about using it. According to Nikki there is a lot of shame around Ozempic and she thinks it's coming from a pretty silly place.
Nikki believes the shame comes from "thin people who want you to stay fat." She thinks they are "so mad" that people are losing weight because "that's all they have." She joked that thin people are secretly upset because suddenly people who were previously considered bigger might become the "total package" and threaten their social standing. That is classic Nikki humor right there - edgy and making you think.
She also addressed the common criticism that Ozempic is taking medication away from people with diabetes who really need it. Nikki was not buying that argument. She said it is "suddenly all these thin white women are like 'diabetics need their meds.' No I think you’re upset that Kathy Bates has a thigh gap." She is basically saying she thinks the outrage is not really about diabetes medication access but more about body image and jealousy in Hollywood and beyond. Nikki never shies away from saying what others are afraid to even think.
Plastic Surgery? Nikki Glaser Says 'Do It Subtly' and Jokes About Her 2026 Facelift Plans

Ozempic wasn't the only topic Nikki tackled. She also talked about plastic surgery and she is just as open-minded about that. Nikki joked that she is planning to get a facelift in August 2026. But she has a strategy for it - subtlety is key.
Nikki's humorously explained the approach: "You have to do it subtly. You have to do it so they go ‘What’s she doing?’ And you can go ‘Just meditating more.’" She is making fun of the common celebrity denial and deflection when it comes to cosmetic procedures. She added the typical excuses people use "I’m drinking more water. I’m just working on my gut health so my brow has been lowered two inches." The sarcasm is strong with Nikki.
But under the jokes there's a real point. Nikki does not see anything wrong with plastic surgery. She thinks it can be a "wise investment" and that there is too much "stigma" around it. She said "There’s maybe a little bit of sadness to it but I kinda also am like well it makes my life better. People treat you better when you’re hotter. It’s just a fact. It’s a sad fact of life.” Nikki is not afraid to acknowledge the often superficial nature of Hollywood and society while also claiming agency over her own choices.
From Serious to Seriously Gross: Nikki Glaser's Airport Tampon Mishap Story (Maybe Skip Lunch for This One)

Beyond Ozempic and plastic surgery Nikki also shared a personal story that is well… very Nikki Glaser. It is about an airport mishap involving tampons and let's just say it is not for the faint of heart or anyone eating lunch. While the source articles don't give specific details the title mentions it and it sounds like a classic over-share moment from Nikki. If you know Nikki's Comedy you know she is not afraid to get real and sometimes that means getting a little graphic and a little uncomfortable in a hilarious way. We will have to wait for the full story but knowing Nikki it is probably both cringe-worthy and laugh-out-loud funny.
Nikki Glaser: Unapologetically Honest and Always Ready to Spark a Conversation

Nikki Glaser's recent interviews show why she is one of the most talked-about comedians right now. She is not afraid to tackle sensitive subjects like weight loss drugs and cosmetic surgery. She says what she thinks even if it is controversial or a little uncomfortable. Whether you agree with her or not Nikki Glaser definitely makes you think and laugh maybe even at the same time. She is definitely not afraid to push boundaries and that is exactly why so many people find her so funny and fascinating.